Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators

Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules 33-11 and KH-4-43 that inhibit E3 CRL4’s core ligase complex and exhibit anticanc...

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Detalles Bibliográficos
Autores principales: Wu, Kenneth, Hopkins, Benjamin D., Sanchez, Roberto, DeVita, Robert J., Pan, Zhen-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486283/
https://www.ncbi.nlm.nih.gov/pubmed/34604860
http://dx.doi.org/10.33696/Signaling.2.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486283/
https://www.ncbi.nlm.nih.gov/pubmed/34604860
http://dx.doi.org/10.33696/Signaling.2.051

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