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Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators
Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules 33-11 and KH-4-43 that inhibit E3 CRL4’s core ligase complex and exhibit anticanc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486283/ https://www.ncbi.nlm.nih.gov/pubmed/34604860 http://dx.doi.org/10.33696/Signaling.2.051 |