Endoplasmic reticulum tubules limit the size of misfolded protein condensates

The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to lysosomes. When the delivery of Akita puncta to lyso...

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Detalles Bibliográficos
Autores principales: Parashar, Smriti, Chidambaram, Ravi, Chen, Shuliang, Liem, Christina R, Griffis, Eric, Lambert, Gerard G, Shaner, Nathan C, Wortham, Matthew, Hay, Jesse C, Ferro-Novick, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486381/
https://www.ncbi.nlm.nih.gov/pubmed/34467852
http://dx.doi.org/10.7554/eLife.71642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486381/
https://www.ncbi.nlm.nih.gov/pubmed/34467852
http://dx.doi.org/10.7554/eLife.71642

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