Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support tumor metabolism and cell proliferation. In particular, KRAS mutant cancer cells exploit amino acids (AAs) such as glutamine and leucine, to accelerate energy metabolism, redox balance through glutathione synthesi...

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Detalles Bibliográficos
Autores principales: Kandasamy, Palanivel, Zlobec, Inti, Nydegger, Damian T., Pujol‐Giménez, Jonai, Bhardwaj, Rajesh, Shirasawa, Senji, Tsunoda, Toshiyuki, Hediger, Matthias A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486573/
https://www.ncbi.nlm.nih.gov/pubmed/34003553
http://dx.doi.org/10.1002/1878-0261.12999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486573/
https://www.ncbi.nlm.nih.gov/pubmed/34003553
http://dx.doi.org/10.1002/1878-0261.12999

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