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Removal of CD276(+) cells from haploidentical memory T-cell grafts significantly lowers the risk of GVHD

Detrimental graft-versus-host disease (GVHD) still remains a major cause of death in hematopoietic stem cell transplantation (HSCT). The recently explored depletion of naive cells from mobilized grafts (CD45RA depletion) has shown considerable promise, yet is unable to eliminate the incidence of GVH...

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Detalles Bibliográficos
Autores principales: Hashimoto, Hisayoshi, Kasteleiner, Patrick, Kressin, Jakob, Müller, Friederike, Bühring, Hans-Jörg, Handgretinger, Rupert, Schilbach, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486669/
https://www.ncbi.nlm.nih.gov/pubmed/33976380
http://dx.doi.org/10.1038/s41409-021-01307-9