Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker, varies with sex and ancestry, and influences smoking cessation and disease risk. We conduc...

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Detalles Bibliográficos
Autores principales: Chenoweth, Meghan J., Cox, Lisa Sanderson, Nollen, Nikki L., Ahluwalia, Jasjit S., Benowitz, Neal L., Lerman, Caryn, Knight, Jo, Tyndale, Rachel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486765/
https://www.ncbi.nlm.nih.gov/pubmed/34599228
http://dx.doi.org/10.1038/s41598-021-98883-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486765/
https://www.ncbi.nlm.nih.gov/pubmed/34599228
http://dx.doi.org/10.1038/s41598-021-98883-z

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