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Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies

Ongoing increases in the size of human genotype and phenotype collections offer the promise of improved understanding of the genetics of complex diseases. In addition to the biological insights that can be gained from the nature of the variants that contribute to the genetic component of complex tra...

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Detalles Bibliográficos
Autores principales: Bennett, Declan, O’Shea, Donal, Ferguson, John, Morris, Derek, Seoighe, Cathal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486788/
https://www.ncbi.nlm.nih.gov/pubmed/34599249
http://dx.doi.org/10.1038/s41598-021-99031-3