NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents....

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Detalles Bibliográficos
Autores principales: Huang, Can, Santofimia-Castaño, Patricia, Liu, Xi, Xia, Yi, Peng, Ling, Gotorbe, Célia, Neira, Jose Luis, Tang, Daolin, Pouyssegur, Jacques, Iovanna, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486797/
https://www.ncbi.nlm.nih.gov/pubmed/34599149
http://dx.doi.org/10.1038/s41420-021-00662-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486797/
https://www.ncbi.nlm.nih.gov/pubmed/34599149
http://dx.doi.org/10.1038/s41420-021-00662-2

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