Complex small-world regulatory networks emerge from the 3D organisation of the human genome

The discovery that overexpressing one or a few critical transcription factors can switch cell state suggests that gene regulatory networks are relatively simple. In contrast, genome-wide association studies (GWAS) point to complex phenotypes being determined by hundreds of loci that rarely encode tr...

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Detalles Bibliográficos
Autores principales: Brackley, C. A., Gilbert, N., Michieletto, D., Papantonis, A., Pereira, M. C. F., Cook, P. R., Marenduzzo, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486811/
https://www.ncbi.nlm.nih.gov/pubmed/34599163
http://dx.doi.org/10.1038/s41467-021-25875-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486811/
https://www.ncbi.nlm.nih.gov/pubmed/34599163
http://dx.doi.org/10.1038/s41467-021-25875-y

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