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Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells

Regulatory dependencies in molecular networks are the basis of dynamic behaviors affecting the phenotypical landscape. With the advance of high throughput technologies, the detail of omics data has arrived at the single-cell level. Nevertheless, new strategies are required to reconstruct regulatory...

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Detalles Bibliográficos
Autores principales: Schwab, Julian D., Ikonomi, Nensi, Werle, Silke D., Weidner, Felix M., Geiger, Hartmut, Kestler, Hans A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487005/
https://www.ncbi.nlm.nih.gov/pubmed/34630946
http://dx.doi.org/10.1016/j.csbj.2021.09.012