Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity

Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β (Aβ) production. Hypoxia significantly a...

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Detalles Bibliográficos
Autores principales: Yuan, Yuan, Chen, Jingjiong, Ge, Xuhua, Deng, Jiangshan, Xu, Xiaofeng, Zhao, Yuwu, Wang, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487051/
https://www.ncbi.nlm.nih.gov/pubmed/34403210
http://dx.doi.org/10.1002/2211-5463.13273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487051/
https://www.ncbi.nlm.nih.gov/pubmed/34403210
http://dx.doi.org/10.1002/2211-5463.13273

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