Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

BACKGROUND: Tissue transglutaminase (TG2), an enzyme overexpressed in cancer cells, promotes metastasis and resistance to chemotherapy. Its distinct effects in cancer versus the host compartments have not been elucidated. METHODS: Here, by using a TG2(-/-) syngeneic ovarian cancer mouse model, we as...

Descripción completa

Detalles Bibliográficos
Autores principales: Sima, Livia Elena, Chen, Siqi, Cardenas, Horacio, Zhao, Guangyuan, Wang, Yinu, Ivan, Cristina, Huang, Hao, Zhang, Bin, Matei, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487211/
https://www.ncbi.nlm.nih.gov/pubmed/34593619
http://dx.doi.org/10.1136/jitc-2021-002682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487211/
https://www.ncbi.nlm.nih.gov/pubmed/34593619
http://dx.doi.org/10.1136/jitc-2021-002682

Ejemplares similares