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Linagliptin Protects Human SH-SY5Y Neuroblastoma Cells against Amyloid-β Cytotoxicity via the Activation of Wnt1 and Suppression of IL-6 Release

BACKGROUND: Alzheimer’s disease is one of the neurodegenerative disorders typified by the aggregate of Aβ and phosphorylated tau protein. Oxidative stress and neuroinflammation, because of Aβ peptides, are strongly involved in the pathophysiology of AD. Linagliptin shows neuroprotective properties a...

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Detalles Bibliográficos
Autores principales: Sedighi, Mohsen, Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487681/
https://www.ncbi.nlm.nih.gov/pubmed/34425652
http://dx.doi.org/10.52547/ibj.25.5.343