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CoMM-S(4): A Collaborative Mixed Model Using Summary-Level eQTL and GWAS Datasets in Transcriptome-Wide Association Studies

Motivation: Genome-wide association studies (GWAS) have achieved remarkable success in identifying SNP-trait associations in the last decade. However, it is challenging to identify the mechanisms that connect the genetic variants with complex traits as the majority of GWAS associations are in non-co...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Yeung, Kar-Fu, Liu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488198/
https://www.ncbi.nlm.nih.gov/pubmed/34616426
http://dx.doi.org/10.3389/fgene.2021.704538