Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target. The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors. The d...

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Detalles Bibliográficos
Autores principales: Warfield, Becka M., Casalvieri, Kimberly A., Matheson, Christopher J., Backos, Donald S., Reigan, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488253/
https://www.ncbi.nlm.nih.gov/pubmed/34632023
http://dx.doi.org/10.1016/j.dib.2021.107433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488253/
https://www.ncbi.nlm.nih.gov/pubmed/34632023
http://dx.doi.org/10.1016/j.dib.2021.107433

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