Targeting DNA Homologous Repair Proficiency With Concomitant Topoisomerase II and c-Abl Inhibition

Critical DNA repair pathways become deranged during cancer development. This vulnerability may be exploited with DNA-targeting chemotherapy. Topoisomerase II inhibitors induce double-strand breaks which, if not repaired, are detrimental to the cell. This repair process requires high-fidelity functio...

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Detalles Bibliográficos
Autores principales: Siddiqui, Arafat, Tumiati, Manuela, Joko, Alia, Sandholm, Jouko, Roering, Pia, Aakko, Sofia, Vainionpää, Reetta, Kaipio, Katja, Huhtinen, Kaisa, Kauppi, Liisa, Tuomela, Johanna, Hietanen, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488401/
https://www.ncbi.nlm.nih.gov/pubmed/34616682
http://dx.doi.org/10.3389/fonc.2021.733700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488401/
https://www.ncbi.nlm.nih.gov/pubmed/34616682
http://dx.doi.org/10.3389/fonc.2021.733700

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