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NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification

Lysosomes are key organelles maintaining cellular homeostasis in health and disease. Here, we report the identification of N‐deacetylase and N‐sulfotransferase 3 (NDST3) as a potent regulator of lysosomal functions through an unbiased genetic screen. NDST3 constitutes a new member of the histone dea...

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Detalles Bibliográficos
Autores principales: Tang, Qing, Liu, Mingming, Liu, Yang, Hwang, Ran‐Der, Zhang, Tao, Wang, Jiou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488563/
https://www.ncbi.nlm.nih.gov/pubmed/34435379
http://dx.doi.org/10.15252/embj.2020107204