Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling

T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the local depletion of large receptor-type phosphatases from “close contacts” formed when T cells interact with surfaces presenting agonistic TCR ligands, but exactly how the ligands potentiate signaling is unclea...

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Detalles Bibliográficos
Autores principales: Chen, Kevin Y., Jenkins, Edward, Körbel, Markus, Ponjavic, Aleks, Lippert, Anna H., Santos, Ana Mafalda, Ashman, Nicole, O'Brien-Ball, Caitlin, McBride, Jemma, Klenerman, David, Davis, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488633/
https://www.ncbi.nlm.nih.gov/pubmed/34526387
http://dx.doi.org/10.1073/pnas.2024250118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488633/
https://www.ncbi.nlm.nih.gov/pubmed/34526387
http://dx.doi.org/10.1073/pnas.2024250118

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