Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments

BACKGROUND: The human tumor microenvironment (TME) is a complex and dynamic milieu of diverse acellular and cellular components, creating an immunosuppressive environment, which contributes to tumor progression. We have previously shown that phosphatidylserine (PS) expressed on the surface of exosom...

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Detalles Bibliográficos
Autores principales: Bhatta, Maulasri, Shenoy, Gautam N, Loyall, Jenni L, Gray, Brian D, Bapardekar, Meghana, Conway, Alexis, Minderman, Hans, Kelleher Jr, Raymond J, Carreno, Beatriz M, Linette, Gerald, Shultz, Leonard D, Odunsi, Kunle, Balu-Iyer, Sathy V, Pak, Koon Yan, Bankert, Richard B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488709/
https://www.ncbi.nlm.nih.gov/pubmed/34599030
http://dx.doi.org/10.1136/jitc-2021-003148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488709/
https://www.ncbi.nlm.nih.gov/pubmed/34599030
http://dx.doi.org/10.1136/jitc-2021-003148

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