Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment

BACKGROUND: The major challenge of antitumor immunotherapy is dealing with the immunosuppressive tumor microenvironment, which involves immature myeloid cell accumulation that results in T cell dysfunction. Myeloid cell activation is induced by Toll-like receptor agonists. Additionally, granulocyte/...

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Detalles Bibliográficos
Autores principales: Yan, Wan-Lun, Wu, Chiao-Chieh, Shen, Kuan-Yin, Liu, Shih-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488721/
https://www.ncbi.nlm.nih.gov/pubmed/34599024
http://dx.doi.org/10.1136/jitc-2021-002758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488721/
https://www.ncbi.nlm.nih.gov/pubmed/34599024
http://dx.doi.org/10.1136/jitc-2021-002758

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