TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer

Tropomyosin receptor kinase (TRK) fusion is one of the oncogenic driver causes of colon cancer, and tropomyosin 3-neurotrophic receptor tyrosine kinase 1 (TPM3-NTRK1) fusion has been detected in the KM12SM cell line. In the present study, we investigated anticancer mechanisms in the KM12SM cell line...

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Detalles Bibliográficos
Autores principales: Sohn, Sung-Hwa, Sul, Hee Jung, Kim, Bohyun, Kim, Bum Jun, Kim, Hyeong Su, Zang, Dae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489125/
https://www.ncbi.nlm.nih.gov/pubmed/34659525
http://dx.doi.org/10.7150/jca.60845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489125/
https://www.ncbi.nlm.nih.gov/pubmed/34659525
http://dx.doi.org/10.7150/jca.60845

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