Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR

Structure-based drug development suffers from high attrition rates due to the poor activity of lead compounds in cellular and animal models caused by low cell penetrance, off-target binding or changes in the conformation of the target protein in the cellular environment. The latter two effects cause...

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Detalles Bibliográficos
Autores principales: Luchinat, Enrico, Barbieri, Letizia, Cremonini, Matteo, Pennestri, Matteo, Nocentini, Alessio, Supuran, Claudiu T., Banci, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Ccp4
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489230/
https://www.ncbi.nlm.nih.gov/pubmed/34605430
http://dx.doi.org/10.1107/S2059798321009037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489230/
https://www.ncbi.nlm.nih.gov/pubmed/34605430
http://dx.doi.org/10.1107/S2059798321009037

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