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Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR
Structure-based drug development suffers from high attrition rates due to the poor activity of lead compounds in cellular and animal models caused by low cell penetrance, off-target binding or changes in the conformation of the target protein in the cellular environment. The latter two effects cause...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489230/ https://www.ncbi.nlm.nih.gov/pubmed/34605430 http://dx.doi.org/10.1107/S2059798321009037 |