Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications

Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the pyruvate dehydrogenase complex regulator (PdhR) in Escheri...

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Detalles Bibliográficos
Autores principales: Anand, Amitesh, Olson, Connor A., Sastry, Anand V., Patel, Arjun, Szubin, Richard, Yang, Laurence, Feist, Adam M., Palsson, Bernhard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489512/
https://www.ncbi.nlm.nih.gov/pubmed/33826886
http://dx.doi.org/10.1016/j.celrep.2021.108961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489512/
https://www.ncbi.nlm.nih.gov/pubmed/33826886
http://dx.doi.org/10.1016/j.celrep.2021.108961

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