Cargando…

Effective gene expression prediction from sequence by integrating long-range interactions

How noncoding DNA determines gene expression in different cell types is a major unsolved problem, and critical downstream applications in human genetics depend on improved solutions. Here, we report substantially improved gene expression prediction accuracy from DNA sequences through the use of a de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avsec, Žiga, Agarwal, Vikram, Visentin, Daniel, Ledsam, Joseph R., Grabska-Barwinska, Agnieszka, Taylor, Kyle R., Assael, Yannis, Jumper, John, Kohli, Pushmeet, Kelley, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490152/ https://www.ncbi.nlm.nih.gov/pubmed/34608324 http://dx.doi.org/10.1038/s41592-021-01252-x

Ejemplares similares

The 9th annual computational and systems neuroscience (cosyne) meeting
por: Grabska-Barwińska, Agnieszka, et al.
Publicado: (2012)

Modeling positional effects of regulatory sequences with spline transformations increases prediction accuracy of deep neural networks
por: Avsec, Žiga, et al.
Publicado: (2018)

Nasal Chemosensory-Stimulation Evoked Activity Patterns in the Rat Trigeminal Ganglion Visualized by In Vivo Voltage-Sensitive Dye Imaging
por: Rothermel, Markus, et al.
Publicado: (2011)

Predicting mean ribosome load for 5’UTR of any length using deep learning
por: Karollus, Alexander, et al.
Publicado: (2021)

Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast
por: Cheng, Jun, et al.
Publicado: (2017)

Machine Learning Demonstrates High Accuracy for Disease Diagnosis and Prognosis in Plastic Surgery
por: Mantelakis, Angelos, et al.
Publicado: (2021)

The genetic and biochemical determinants of mRNA degradation rates in mammals
por: Agarwal, Vikram, et al.
Publicado: (2022)

Protein structure prediction using multiple deep neural networks in the 13th Critical Assessment of Protein Structure Prediction (CASP13)
por: Senior, Andrew W., et al.
Publicado: (2019)

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
por: Varadi, Mihaly, et al.
Publicado: (2021)

MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
por: Cheng, Jun, et al.
Publicado: (2019)

DCE-MRI for Early Prediction of Response in Hepatocellular Carcinoma after TACE and Sorafenib Therapy: A Pilot Study
por: Saito, Kazuhiro, et al.
Publicado: (2018)

The landscape of alternative polyadenylation in single cells of the developing mouse embryo
por: Agarwal, Vikram, et al.
Publicado: (2021)

Genome-wide integration site detection using Cas9 enriched amplification-free long-range sequencing
por: van Haasteren, Joost, et al.
Publicado: (2020)

Comportamiento del consumidor /
por: Assael, Henry
Publicado: (1999)

Base-resolution models of transcription factor binding reveal soft motif syntax
por: Avsec, Žiga, et al.
Publicado: (2021)

Examining pre-service teachers regulation in distance and traditional preschool design and technology education
por: Kurent, Brina, et al.
Publicado: (2023)

Relationship between ankle strength and range of motion and postural stability during single-leg quiet stance in trained athletes
por: Trajković, Nebojša, et al.
Publicado: (2021)

Commonly Asked Questions in Thermodynamics
por: Assael, Marc J
Publicado: (2011)

The economy for clinical science in oral and maxillofacial surgery
por: Assael, Leon A.
Publicado: (2015)

Residency Education in Oral and Maxillofacial Surgery: A New Curriculum Framework
por: Assael, Leon A.
Publicado: (2022)

Associations of Diabetic Retinopathy with Retinal Neurodegeneration on the Background of Diabetes Mellitus. Overview of Recent Medical Studies with an Assessment of the Impact on Healthcare systems
por: Muc, Rafał, et al.
Publicado: (2018)

Discovering faster matrix multiplication algorithms with reinforcement learning
por: Fawzi, Alhussein, et al.
Publicado: (2022)

Restoring and attributing ancient texts using deep neural networks
por: Assael, Yannis, et al.
Publicado: (2022)

The Kipoi repository accelerates community exchange and reuse of predictive models for genomics
por: Avsec, Žiga, et al.
Publicado: (2019)

Automated analysis of retinal imaging using machine learning techniques for computer vision
por: De Fauw, Jeffrey, et al.
Publicado: (2017)

Identification and Characterization of Wilt and Salt Stress-Responsive MicroRNAs in Chickpea through High-Throughput Sequencing
por: Kohli, Deshika, et al.
Publicado: (2014)

Reluctance and Willingness for Organ Donation After Death Among the Slovene General Population
por: Berzelak, Nejc, et al.
Publicado: (2019)

COVID-19 vaccination intention, confidence and hesitancy among working population in Slovenia: A Cross-Sectional Survey
por: Avsec, Lara, et al.
Publicado: (2022)

Discovery of parvovirus-related sequences in an unexpected broad range of animals
por: François, S., et al.
Publicado: (2016)

An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target
por: Jumper, N., et al.
Publicado: (2016)

Electrical and synaptic integration of glioma into neural circuits
por: Venkatesh, Humsa S., et al.
Publicado: (2019)

Psychological Functioning of Slovene Adults during the COVID-19 Pandemic: Does Resilience Matter?
por: Kavčič, Tina, et al.
Publicado: (2020)

Resilience matters: Explaining the association between personality and psychological functioning during the COVID-19 pandemic
por: Zager Kocjan, Gaja, et al.
Publicado: (2021)

Coping profiles and their association with psychological functioning: A latent profile analysis of coping strategies during the COVID-19 pandemic
por: Kavčič, Tina, et al.
Publicado: (2022)

Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology
por: Jumper, N., et al.
Publicado: (2017)

Interval Timing by Long-Range Temporal Integration
por: Simen, Patrick, et al.
Publicado: (2011)

Long-range integration of repressive and patterning inputs
por: Webber, Jemma L, et al.
Publicado: (2014)

Mapping single-cell data to reference atlases by transfer learning
por: Lotfollahi, Mohammad, et al.
Publicado: (2021)

MD 3584: Long-Range Beam-Beam 2018
por: Karastathis, Nikos, et al.
Publicado: (2020)

Advancing mathematics by guiding human intuition with AI
por: Davies, Alex, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hiik3n9cn5j4i68s3dild014hp