Cargando…

Leu-to-Phe substitution at prM(146) decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice

Zika virus (ZIKV) is a mosquito-borne flavivirus that causes febrile illness. The recent spread of ZIKV from Asia to the Americas via the Pacific region has revealed unprecedented features of ZIKV, including transplacental congenital infection causing microcephaly. Amino acid changes have been hypot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inagaki, Takuya, Taniguchi, Satoshi, Kawai, Yasuhiro, Maeki, Takahiro, Nakayama, Eri, Tajima, Shigeru, Takeyama, Haruko, Lim, Chang Kweng, Saijo, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490429/ https://www.ncbi.nlm.nih.gov/pubmed/34608212 http://dx.doi.org/10.1038/s41598-021-99086-2

Ejemplares similares

E and prM proteins of genotype V Japanese encephalitis virus are required for its increased virulence in mice
por: Tajima, Shigeru, et al.
Publicado: (2019)

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR(-/-) mice maps to prM residues conserved amongst African genotype viruses
por: Nakayama, Eri, et al.
Publicado: (2021)

Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) Is Associated with In Vitro Growth Characteristics of JEV
por: Tajima, Shigeru, et al.
Publicado: (2020)

Immunogenicity and Protective Ability of Genotype I-Based Recombinant Japanese Encephalitis Virus (JEV) with Attenuation Mutations in E Protein against Genotype V JEV
por: Tajima, Shigeru, et al.
Publicado: (2021)

Characterization of large and small-plaque variants in the Zika virus clinical isolate ZIKV/Hu/S36/Chiba/2016
por: Kato, Fumihiro, et al.
Publicado: (2017)

Increased growth ability and pathogenicity of American- and Pacific-subtype Zika virus (ZIKV) strains compared with a Southeast Asian-subtype ZIKV strain
por: Kawai, Yasuhiro, et al.
Publicado: (2019)

Importation of Zika Virus from Vietnam to Japan, November 2016
por: Hashimoto, Takehiro, et al.
Publicado: (2017)

Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice
por: Nakayama, Eri, et al.
Publicado: (2021)

Analysis of the Function of the Lymphocytic Choriomeningitis Virus S Segment Untranslated Region on Growth Capacity In Vitro and on Virulence In Vivo
por: Taniguchi, Satoshi, et al.
Publicado: (2020)

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
por: Nambala, Peter, et al.
Publicado: (2018)

The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity
por: Li, Ge, et al.
Publicado: (2019)

Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly
por: Goellner, Sarah, et al.
Publicado: (2023)

Dengue Virus Type 2 in Travelers Returning to Japan from Sri Lanka, 2017
por: Tsuboi, Motoyuki, et al.
Publicado: (2017)

The prM-independent packaging of pseudotyped Japanese encephalitis virus
por: Lee, Hee Jung, et al.
Publicado: (2009)

An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens
por: Jin, Hongli, et al.
Publicado: (2021)

The Safe Baculovirus-Based PrM/E DNA Vaccine Protected Fetuses against Zika Virus in A129 Mice
por: Choi, Hanul, et al.
Publicado: (2021)

The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation
por: Setoh, Yin Xiang, et al.
Publicado: (2015)

C-Terminal Helical Domains of Dengue Virus Type 4 E Protein Affect the Expression/Stability of prM Protein and Conformation of prM and E Proteins
por: Tsai, Wen-Yang, et al.
Publicado: (2012)

Evaluation of the Complex p.[Leu467Phe;Phe508del] CFTR Allele in the Intestinal Organoids Model: Implications for Therapy
por: Kondratyeva, Elena, et al.
Publicado: (2022)

Recombinant Measles AIK-C Vaccine Strain Expressing the prM-E Antigen of Japanese Encephalitis Virus
por: Higuchi, Akira, et al.
Publicado: (2016)

Dengue Virus Exported from Côte d’Ivoire to Japan, June 2017
por: Suzuki, Tetsuya, et al.
Publicado: (2017)

Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein
por: Liu, Xinglong, et al.
Publicado: (2018)

Comprehensive mapping infection-enhancing epitopes of dengue pr protein using polyclonal antibody against prM
por: Luo, Yayan, et al.
Publicado: (2015)

Mutation in West Nile Virus Structural Protein prM during Human Infection
por: Lustig, Yaniv, et al.
Publicado: (2016)

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling
por: Sui, Liyan, et al.
Publicado: (2023)

A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity
por: Lin, Chen-Sheng, et al.
Publicado: (2022)

PTPN11 c.853T>C (p.Phe285Leu) mutation in Noonan syndrome with chylothorax
por: Watanabe, Daisuke, et al.
Publicado: (2022)

Dengue Patients Exhibit Higher Levels of PrM and E Antibodies Than Their Asymptomatic Counterparts
por: Yeo, Adeline Syin Lian, et al.
Publicado: (2015)

Development and biochemical characteristics of a monoclonal antibody against prM protein of Tembusu virus
por: Zhu, Siming, et al.
Publicado: (2023)

MGMT Leu84Phe Polymorphism Contributes to Cancer Susceptibility: Evidence from 44 Case-Control Studies
por: Liu, Jun, et al.
Publicado: (2013)

Hb Heathrow [β103(G5)Phe→Leu], a First Report in an Asian Patient with Erythrocytosis
por: Shin, Sang-Yong, et al.
Publicado: (2017)

Multi-Factor Regulation of the Master Modulator LeuO for the Cyclic-(Phe-Pro) Signaling Pathway in Vibrio vulnificus
por: Park, Na-Young, et al.
Publicado: (2019)

Novel RHD allele with c.333C>G change predicted to encode p.Phe111Leu
por: Alluin, Gauthier, et al.
Publicado: (2022)

Genotype-Dependent Immunogenicity of Dengue Virus Type 2 Asian I and Asian/American Genotypes in Common Marmoset (Callithrix jacchus): Discrepancy in Neutralizing and Infection-Enhancing Antibody Levels between Genotypes
por: Azami, Nor Azila Muhammad, et al.
Publicado: (2021)

A Human PrM Antibody That Recognizes a Novel Cryptic Epitope on Dengue E Glycoprotein
por: Chan, Annie Hoi Yi, et al.
Publicado: (2012)

Antibodies against prM protein distinguish between previous infection with dengue and Japanese encephalitis viruses.
por: Cardosa, Mary Jane, et al.
Publicado: (2002)

Systematic Bioinformatic Approach for Prediction of Linear B-Cell Epitopes on Dengue E and prM Protein
por: Nadugala, Mahesha N., et al.
Publicado: (2016)

Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection
por: Ishag, Hassan Z.A., et al.
Publicado: (2016)

Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence
por: Xiong, Junyao, et al.
Publicado: (2022)

prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis
por: A. Dowd, Kimberly, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_q1epkkdnha58rqmat3rapph60f