Cargando…

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

A great hurdle in the production of synthetic polypeptides lies in the access of N-carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe, and protection of side-chain functional groups. Here we report a robust method for preparing unprotected NCA monomers in air and u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Zi-You, Zhang, Zhengchu, Wang, Shuo, Lu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490447/ https://www.ncbi.nlm.nih.gov/pubmed/34608139 http://dx.doi.org/10.1038/s41467-021-25689-y

Ejemplares similares

Photo-On-Demand Synthesis of α-Amino Acid N-Carboxyanhydrides with Chloroform
por: Sugimoto, Toshiyuki, et al.
Publicado: (2022)

N-Heterocyclic Carbene-Catalyzed Random Copolymerization of N-Carboxyanhydrides of α-Amino Acids
por: Eom, Kuen Hee, et al.
Publicado: (2021)

Strategies to Fabricate Polypeptide-Based Structures via Ring-Opening Polymerization of N-Carboxyanhydrides
por: González-Henríquez, Carmen M., et al.
Publicado: (2017)

Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
por: Nie, Yanzhao, et al.
Publicado: (2018)

A nanoscale MOF-based heterogeneous catalytic system for the polymerization of N-carboxyanhydrides enables direct routes toward both polypeptides and related hybrid materials
por: Liu, Ying, et al.
Publicado: (2023)

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes
por: Izgu, Enver Cagri, et al.
Publicado: (2016)

Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
por: Wu, Yueming, et al.
Publicado: (2018)

Synthesis of poly-α/β-peptides with tunable sequence via the copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride
por: Zhou, Min, et al.
Publicado: (2021)

Density Functional Theory Studies on the Synthesis of Poly(α-Amino Acid)s Via the Amine-Mediated Ring Opening Polymerizations of N-Carboxyanhydrides and N-Thiocarboxyanhydrides
por: Bai, Tianwen, et al.
Publicado: (2021)

Two-Dimensional Controlled Syntheses of Polypeptide Molecular Brushes via N-Carboxyanhydride Ring-Opening Polymerization and Ring-Opening Metathesis Polymerization
por: Fan, Jingwei, et al.
Publicado: (2017)

Stereoselective photoredox ring-opening polymerization of O-carboxyanhydrides
por: Feng, Quanyou, et al.
Publicado: (2018)

Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether
por: Xia, Yingchun, et al.
Publicado: (2021)

Clickable Polyprolines from Azido-proline N-Carboxyanhydride
por: Detwiler, Rachel E., et al.
Publicado: (2023)

Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride
por: Hu, Yali, et al.
Publicado: (2022)

Catalytic Asymmetric Synthesis of Unprotected β(2)-Amino Acids
por: Zhu, Chendan, et al.
Publicado: (2021)

Synthesis and Characterization of Macroinitiators Based on Polyorganophosphazenes for the Ring Opening Polymerization of N-Carboxyanhydrides
por: Zashikhina, Natalia, et al.
Publicado: (2021)

Living Ring-Opening Polymerization of O-Carboxyanhydrides: The Search for Catalysts
por: Zhong, Yongliang, et al.
Publicado: (2018)

Crystal structure of β-benzyl dl-aspartate N-carboxyanhydride
por: Kanazawa, Hitoshi, et al.
Publicado: (2017)

Direct N-alkylation of unprotected amino acids with alcohols
por: Yan, Tao, et al.
Publicado: (2017)

Enantioselective extraction of unprotected amino acids coupled with racemization
por: Huang, Haofei, et al.
Publicado: (2021)

Facile Synthesis of Triphenylamine Based Hyperbranched Polymer for Organic Field Effect Transistors
por: Bathula, Chinna, et al.
Publicado: (2019)

Photocatalyst-independent photoredox ring-opening polymerization of O-carboxyanhydrides: stereocontrol and mechanism
por: Zhong, Yongliang, et al.
Publicado: (2021)

Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
por: Saavedra, Beatriz, et al.
Publicado: (2023)

pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy
por: Yan, Rui, et al.
Publicado: (2020)

Growing Hyperbranched Polymers Using Natural Sunlight
por: Yan, Jun-Jie, et al.
Publicado: (2013)

Catalytic asymmetric Tsuji–Trost α−benzylation reaction of N-unprotected amino acids and benzyl alcohol derivatives
por: Liu, Jian-Hua, et al.
Publicado: (2022)

Chiral aldehyde catalysis enables direct asymmetric α-substitution reaction of N-unprotected amino acids with halohydrocarbons
por: Shen, Hao-Ran, et al.
Publicado: (2023)

The Synthesis and Characterization of Hydroxyapatite-β-Alanine Modified by Grafting Polymerization of γ-Benzyl-l-glutamate-N-carboxyanhydride
por: Shan, Yukai, et al.
Publicado: (2013)

Facile Synthesis of Functionalised Hyperbranched Polymers for Application as Novel, Low Viscosity Lubricant Formulation Components
por: Goodwin, Sophie R., et al.
Publicado: (2022)

Hyperbranched Macromolecules: From Synthesis to Applications
por: Jeon, In-Yup, et al.
Publicado: (2018)

Recyclable and Stable α-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected α-Amino Acids
por: Shu, Shuangjie, et al.
Publicado: (2019)

Synthesis of hybrid hydrazino peptides: protected vs unprotected chiral α-hydrazino acids
por: Suć, Josipa, et al.
Publicado: (2015)

Facile Synthesis of Cross-linked Hyperbranched Polyamidoamines Dendrimers for Efficient Hg(Ⅱ) Removal From Water
por: Geng, Xue, et al.
Publicado: (2021)

Ring-Opening Polymerization of l-Lactic Acid O-Carboxyanhydrides Initiated by Alkoxy Rare Earth Compounds
por: He, Zhengguo, et al.
Publicado: (2013)

Catalytic α-Arylation of Imines Leading to N-Unprotected Indoles and Azaindoles
por: Marelli, Enrico, et al.
Publicado: (2016)

Design and Synthesis of Hyperbranched Aromatic Polymers for Catalysis
por: Nabae, Yuta, et al.
Publicado: (2018)

Preparation and Application of Amino-Terminated Hyperbranched Magnetic Composites in High-Turbidity Water Treatment
por: Zhao, Yuan, et al.
Publicado: (2023)

Facile Synthesis of Hyperbranched Ethylene Oligomers and Ethylene/Methyl Acrylate Co-oligomers with Different Microscopic Chain Architectures
por: Fan, Huijun, et al.
Publicado: (2021)

Novozym 435-Catalyzed Synthesis of Well-Defined Hyperbranched Aliphatic Poly(β-thioether ester)
por: Wu, Wan-Xia, et al.
Publicado: (2020)

Biocatalytic trifluoromethylation of unprotected phenols
por: Simon, Robert C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3m93i1noegk15kdfeur05ddpgm