Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK

PHLPP2 is a member of the PHLPP family of phosphatases, known to suppress cell growth by inhibiting proliferation or promoting apoptosis. Oncogenic kinases Akt, S6K, and PKC, and pro-apoptotic kinase Mst1, have been recognized as functional targets of the PHLPP family. However, we observed that, in...

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Detalles Bibliográficos
Autores principales: Yan, Yan, Krecke, Karl N., Bapat, Aditi S., Yang, Tingyuan, Lopresti, Michael W., Mashek, Douglas G., Kelekar, Ameeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490465/
https://www.ncbi.nlm.nih.gov/pubmed/34608126
http://dx.doi.org/10.1038/s41419-021-04196-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490465/
https://www.ncbi.nlm.nih.gov/pubmed/34608126
http://dx.doi.org/10.1038/s41419-021-04196-4

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