Cargando…

IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1(+/-) mice display increases atherosclerotic plaque stability

Rationale: Atherosclerosis plaque rupture (PR) is the pathological basis and chief culprit of most acute cardiovascular events and death. Given the complex and important role of macrophage apoptosis and autophagy in affecting plaque stability, an important unanswered question include is whether, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Shaohong, Sun, Song, Cai, Hengxuan, Zou, Xiaoyi, Wang, Shanjie, Hao, Xinran, Wan, Xin, Tian, Jiangtian, Li, Zhaoying, He, Zhongze, Huang, Wei, Liang, Chenchen, Zhang, Zhenming, Yang, Liming, Tian, Jinwei, Yu, Bo, Sun, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490524/ https://www.ncbi.nlm.nih.gov/pubmed/34646375 http://dx.doi.org/10.7150/thno.62797

Ejemplares similares

IRGM in autophagy and viral infections
por: Petkova, Denitsa S., et al.
Publicado: (2013)

Death and Resurrection of the Human IRGM Gene
por: Bekpen, Cemalettin, et al.
Publicado: (2009)

IRGM1 links mitochondrial quality control to autoimmunity
por: Rai, Prashant, et al.
Publicado: (2021)

Irgm1 regulates metabolism and function in T cell subsets
por: Alwarawrah, Yazan, et al.
Publicado: (2022)

IRGM Variants and Susceptibility to Inflammatory Bowel Disease in the German Population
por: Glas, Jürgen, et al.
Publicado: (2013)

mSphere of Influence: Role of IRGM1 in Disease Control
por: Naik, Sumanta Kumar
Publicado: (2021)

Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis
por: Goswami, Apeksha Bharatgiri, et al.
Publicado: (2022)

Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice
por: Wilburn, Kaley M., et al.
Publicado: (2023)

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network
por: Grégoire, Isabel Pombo, et al.
Publicado: (2011)

Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
por: Bahari, Gholamreza, et al.
Publicado: (2012)

Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis
por: Kimura, Tomonori, et al.
Publicado: (2014)

Association of IRGM Gene Mutations with Inflammatory Bowel Disease in the Indian Population
por: Baskaran, Kirankumar, et al.
Publicado: (2014)

Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis
por: Xie, Haojun, et al.
Publicado: (2017)

Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
por: King, Katherine Y., et al.
Publicado: (2011)

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
por: Prescott, Natalie J., et al.
Publicado: (2010)

Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases
por: Yao, Qiu-ming, et al.
Publicado: (2018)

Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer
por: Chen, Xi, et al.
Publicado: (2021)

Race-specific association of an IRGM risk allele with cytokine expression in human subjects
por: Ajayi, Teminioluwa, et al.
Publicado: (2023)

IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis
por: Xia, Fucan, et al.
Publicado: (2013)

IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application
por: Tian, Linlu, et al.
Publicado: (2020)

Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria
por: Singh, Sudha B., et al.
Publicado: (2010)

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
por: Kumar, Suresh, et al.
Publicado: (2018)

Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses
por: Nath, Parej, et al.
Publicado: (2021)

The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?
por: Hunn, Julia P., et al.
Publicado: (2010)

IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn’s disease: A meta-analysis
por: LU, YAO, et al.
Publicado: (2014)

Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization
por: Pradipta, Ariel, et al.
Publicado: (2021)

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection
por: Maric-Biresev, Jelena, et al.
Publicado: (2016)

Localisation and Mislocalisation of the Interferon-Inducible Immunity-Related GTPase, Irgm1 (LRG-47) in Mouse Cells
por: Zhao, Yang O., et al.
Publicado: (2010)

Palmitoylation of the Immunity Related GTPase, Irgm1: Impact on Membrane Localization and Ability to Promote Mitochondrial Fission
por: Henry, Stanley C., et al.
Publicado: (2014)

Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis
por: Fan, Yujia, et al.
Publicado: (2022)

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice
por: Rogala, Allison R., et al.
Publicado: (2018)

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
por: Taylor, Gregory A., et al.
Publicado: (2020)

Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response
por: Jena, Kautilya Kumar, et al.
Publicado: (2020)

IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice
por: Rai, Prashant, et al.
Publicado: (2023)

TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM
por: Sun, Mingchuang, et al.
Publicado: (2023)

IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition
por: Tian, Linlu, et al.
Publicado: (2015)

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains
por: Intemann, Christopher D., et al.
Publicado: (2009)

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins
por: Haldar, Arun K., et al.
Publicado: (2013)

Association between Variants of the Autophagy Related Gene – IRGM and Susceptibility to Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis
por: Lu, Xiao Cheng, et al.
Publicado: (2013)

SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm
por: Zhang, Jichao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fj16tidu52q0771jpn5c4qm5ni