Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. Apo...

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Detalles Bibliográficos
Autores principales: Konings, Sabine C., Torres-Garcia, Laura, Martinsson, Isak, Gouras, Gunnar K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490647/
https://www.ncbi.nlm.nih.gov/pubmed/34621153
http://dx.doi.org/10.3389/fnins.2021.734001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490647/
https://www.ncbi.nlm.nih.gov/pubmed/34621153
http://dx.doi.org/10.3389/fnins.2021.734001

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