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Cochlear Sox2(+) Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules

In the mammalian cochlea, spiral ganglion neurons (SGNs) relay the acoustic information to the central auditory circuits. Degeneration of SGNs is a major cause of sensorineural hearing loss and severely affects the effectiveness of cochlear implant therapy. Cochlear glial cells are able to form sphe...

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Detalles Bibliográficos
Autores principales: Chen, Zhen, Huang, Yuhang, Yu, Chaorong, Liu, Qing, Qiu, Cui, Wan, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490772/
https://www.ncbi.nlm.nih.gov/pubmed/34621745
http://dx.doi.org/10.3389/fcell.2021.728352