Engineering of a Spider Peptide via Conserved Structure-Function Traits Optimizes Sodium Channel Inhibition In Vitro and Anti-Nociception In Vivo

Venom peptides are potent and selective modulators of voltage-gated ion channels that regulate neuronal function both in health and in disease. We previously identified the spider venom peptide Tap1a from the Venezuelan tarantula Theraphosa apophysis that targeted multiple voltage-gated sodium and c...

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Detalles Bibliográficos
Autores principales: Hu, H., Mawlawi, S. E., Zhao, T., Deuis, J. R., Jami, S., Vetter, I., Lewis, R. J., Cardoso, F. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490825/
https://www.ncbi.nlm.nih.gov/pubmed/34621788
http://dx.doi.org/10.3389/fmolb.2021.742457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490825/
https://www.ncbi.nlm.nih.gov/pubmed/34621788
http://dx.doi.org/10.3389/fmolb.2021.742457

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