The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

Accurate Notch signalling is critical for development and homeostasis. Fine‐tuning of Notch–ligand interactions has substantial impact on signalling outputs. Recent structural studies have identified a conserved N‐terminal C2 domain in human Notch ligands which confers phospholipid binding in vitro....

Descripción completa

Detalles Bibliográficos
Autores principales: Martins, Torcato, Meng, Yao, Korona, Boguslawa, Suckling, Richard, Johnson, Steven, Handford, Penny A, Lea, Susan M, Bray, Sarah J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490980/
https://www.ncbi.nlm.nih.gov/pubmed/34347930
http://dx.doi.org/10.15252/embr.202152729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490980/
https://www.ncbi.nlm.nih.gov/pubmed/34347930
http://dx.doi.org/10.15252/embr.202152729

Ejemplares similares