ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable for cancer cells to grow in serine-limiting environments...

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Detalles Bibliográficos
Autores principales: Li, Xingyao, Gracilla, Daniel, Cai, Lun, Zhang, Mingyi, Yu, Xiaolin, Chen, Xiaoguang, Zhang, Junran, Long, Xiaochun, Ding, Han-Fei, Yan, Chunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491098/
https://www.ncbi.nlm.nih.gov/pubmed/34551291
http://dx.doi.org/10.1016/j.celrep.2021.109706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491098/
https://www.ncbi.nlm.nih.gov/pubmed/34551291
http://dx.doi.org/10.1016/j.celrep.2021.109706

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