The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities

[Image: see text] Protein modification by enzymatic breaking and forming of peptide bonds significantly expands the repertoire of genetically encoded protein sequences. The dual protease-ligase legumain exerts the two opposing activities within a single protein scaffold. Primarily localized to the e...

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Detalles Bibliográficos
Autores principales: Dall, Elfriede, Stanojlovic, Vesna, Demir, Fatih, Briza, Peter, Dahms, Sven O., Huesgen, Pitter F., Cabrele, Chiara, Brandstetter, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491156/
https://www.ncbi.nlm.nih.gov/pubmed/34621593
http://dx.doi.org/10.1021/acscatal.1c02057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491156/
https://www.ncbi.nlm.nih.gov/pubmed/34621593
http://dx.doi.org/10.1021/acscatal.1c02057

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