LIR‐1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody‐dependent cellular cytotoxicity

OBJECTIVE: KIR and NKG2A receptors educate human NK cells to stay responsive to cells with diminished HLA class I. Here, we addressed whether the HLA class I‐binding receptor LIR‐1 (LILRB1/ILT2/CD85j), which is widely expressed on human NK cells, can mediate education and contribute to antitumor fun...

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Detalles Bibliográficos
Autores principales: Leijonhufvud, Caroline, Reger, Robert, Segerberg, Filip, Theorell, Jakob, Schlums, Heinrich, Bryceson, Yenan T, Childs, Richard W, Carlsten, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491220/
https://www.ncbi.nlm.nih.gov/pubmed/34631057
http://dx.doi.org/10.1002/cti2.1346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491220/
https://www.ncbi.nlm.nih.gov/pubmed/34631057
http://dx.doi.org/10.1002/cti2.1346

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