Cargando…

Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes

Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are poorly understood. Objectives: To investigate lower airway inflammation and infection in preschool children with different clinical diagnoses undergoing elective bronchoscopy and BAL. Methods: We recruited 136 children...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robinson, Polly F. M., Fontanella, Sara, Ananth, Sachin, Martin Alonso, Aldara, Cook, James, Kaya-de Vries, Daphne, Polo Silveira, Luisa, Gregory, Lisa, Lloyd, Clare, Fleming, Louise, Bush, Andrew, Custovic, Adnan, Saglani, Sejal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491264/ https://www.ncbi.nlm.nih.gov/pubmed/33961755 http://dx.doi.org/10.1164/rccm.202009-3696OC

Ejemplares similares

Remodeling Phenotypes Take Center Stage in the Prediction of Preschool Wheeze Attacks
por: Saglani, Sejal, et al.
Publicado: (2022)

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies
por: Martin Alonso, Aldara, et al.
Publicado: (2017)

Preschool wheezing
por: Santamaria, Francesca
Publicado: (2015)

COVID-19 and preschool wheeze care: lessons learned
por: Makrinioti, Heidi, et al.
Publicado: (2020)

Wheezing in preschool children()
por: Tenero, Laura, et al.
Publicado: (2013)

Patient reported outcomes for preschool children with recurrent wheeze
por: Heidi, Makrinioti, et al.
Publicado: (2019)

Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function
por: Andersson, Cecilia K., et al.
Publicado: (2017)

Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early‐life risk factors and late asthma outcomes
por: Deliu, Matea, et al.
Publicado: (2020)

Causes of variability in latent phenotypes of childhood wheeze
por: Oksel, Ceyda, et al.
Publicado: (2019)

Advances in the pathogenesis and personalised treatment of paediatric asthma
por: Scotney, Elizabeth, et al.
Publicado: (2023)

An Approach to Preschool Wheezing: To Label As Asthma?
por: Van Bever, Hugo P, et al.
Publicado: (2010)

Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates
por: Haider, Sadia, et al.
Publicado: (2022)

Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort
por: Powell, Elizabeth A., et al.
Publicado: (2019)

Spirometry and bronchodilator responsiveness in wheezing preschool children
por: Leiria-Pinto, Paula, et al.
Publicado: (2015)

Biomarkers for Recurrent Wheezing and Asthma in Preschool Children
por: Lee, Yong Ju, et al.
Publicado: (2018)

Preschool Wheezing: Trajectories and Long-Term Treatment
por: Fainardi, Valentina, et al.
Publicado: (2020)

Wheezing in infants and preschoolers: phenotypes and treatment options
por: Shim, Jung Yeon
Publicado: (2022)

A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
por: Granell, Raquel, et al.
Publicado: (2023)

Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids
por: Nagakumar, Prasad, et al.
Publicado: (2019)

Distinguishing Wheezing Phenotypes from Infancy to Adolescence. A Pooled Analysis of Five Birth Cohorts
por: Oksel, Ceyda, et al.
Publicado: (2019)

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study
por: Turner, Steve, et al.
Publicado: (2018)

Innate immune response and bronchiolitis and preschool recurrent wheeze
por: Halfhide, Clare, et al.
Publicado: (2008)

Evolution of Lung Function within Individuals: Clinical Insights and Data-driven Methods
por: Custovic, Adnan, et al.
Publicado: (2022)

Asthma: Closing in on the Biology of a Complex Life-course Disease
por: Bush, Andrew, et al.
Publicado: (2023)

Update on leukotriene receptor antagonists in preschool children wheezing disorders
por: Montella, Silvia, et al.
Publicado: (2012)

A meta-analysis of montelukast for recurrent wheeze in preschool children
por: Hussein, Hasan R., et al.
Publicado: (2017)

Gut microbiota in wheezing preschool children and the association with childhood asthma
por: Bannier, Michiel A. G. E., et al.
Publicado: (2020)

Preschool wheeze prognosis: How do we predict outcome?
por: Graham, LeRoy M.
Publicado: (2006)

Early Life Factors Associated with Preschool Wheezing in Preterm Infants
por: Hsu, Ying-Lun, et al.
Publicado: (2021)

Wheeze is an unreliable endpoint for bronchial methacholine challenges in preschool children
por: Stewart, Lora, et al.
Publicado: (2022)

Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing
por: Wang, Zhili, et al.
Publicado: (2023)

Inflammatory related plasma proteins involved in acute preschool wheeze
por: Holmdahl, Idun, et al.
Publicado: (2023)

Paediatric severe asthma biologics service: from hospital to home
por: Makhecha, Sukeshi, et al.
Publicado: (2021)

P45 - Early exclusive breastfeeding protects from preschool wheeze
por: Guibas, George V, et al.
Publicado: (2014)

Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children
por: Deng, Xiangling, et al.
Publicado: (2021)

Developmental Profiles of Eczema, Wheeze, and Rhinitis: Two Population-Based Birth Cohort Studies
por: Belgrave, Danielle C. M., et al.
Publicado: (2014)

Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media
por: Broadbent, Lindsay, et al.
Publicado: (2020)

Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis
por: Clark, Hannah, et al.
Publicado: (2019)

Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children
por: Bentur, Lea, et al.
Publicado: (2005)

A Disease Model for Wheezing Disorders in Preschool Children Based on Clinicians' Perceptions
por: Spycher, Ben D., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_usf67pthcv01gepj30vfibpgti