Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene

We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde. Oxidation of...

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Detalles Bibliográficos
Autores principales: Ivanova, Maria, Legros, Julien, Poisson, Thomas, Jubault, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491450/
https://www.ncbi.nlm.nih.gov/pubmed/34631154
http://dx.doi.org/10.1007/s41981-021-00205-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491450/
https://www.ncbi.nlm.nih.gov/pubmed/34631154
http://dx.doi.org/10.1007/s41981-021-00205-x

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