Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors

[Image: see text] For the first time, derivatives of 3,7-diazabicyclo[3.3.1]nonane (bispidine) were proposed as potential inhibitors of the SARS-CoV-2 main viral protease (3-chymotrypsin-like, 3CLpro). Based on the created pharmacophore model of the active site of the protease, a group of compounds...

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Detalles Bibliográficos
Autores principales: Shcherbakov, Dmitriy, Baev, Dmitriy, Kalinin, Mikhail, Dalinger, Alexander, Chirkova, Varvara, Belenkaya, Svetlana, Khvostov, Aleksei, Krut’ko, Dmitry, Medved’ko, Aleksei, Volosnikova, Ekaterina, Sharlaeva, Elena, Shanshin, Daniil, Tolstikova, Tatyana, Yarovaya, Olga, Maksyutov, Rinat, Salakhutdinov, Nariman, Vatsadze, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491553/
https://www.ncbi.nlm.nih.gov/pubmed/35043075
http://dx.doi.org/10.1021/acsmedchemlett.1c00299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491553/
https://www.ncbi.nlm.nih.gov/pubmed/35043075
http://dx.doi.org/10.1021/acsmedchemlett.1c00299

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