Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid

Drug solubility is a key parameter controlling oral absorption, but intestinal solubility is difficult to assess in vitro. Human intestinal fluid (HIF) aspirates can be applied but they are variable, difficult to obtain and expensive. Simulated intestinal fluids (SIF) are a useful surrogate but mult...

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Detalles Bibliográficos
Autores principales: Abuhassan, Qamar, Khadra, Ibrahim, Pyper, Kate, Halbert, Gavin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491656/
https://www.ncbi.nlm.nih.gov/pubmed/34419602
http://dx.doi.org/10.1016/j.ejpb.2021.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491656/
https://www.ncbi.nlm.nih.gov/pubmed/34419602
http://dx.doi.org/10.1016/j.ejpb.2021.08.002

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