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Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
Drug solubility is a key parameter controlling oral absorption, but intestinal solubility is difficult to assess in vitro. Human intestinal fluid (HIF) aspirates can be applied but they are variable, difficult to obtain and expensive. Simulated intestinal fluids (SIF) are a useful surrogate but mult...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491656/ https://www.ncbi.nlm.nih.gov/pubmed/34419602 http://dx.doi.org/10.1016/j.ejpb.2021.08.002 |