Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analysis suggests paired-helical filaments (PHFs) from human tauopa...

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Detalles Bibliográficos
Autores principales: Jiang, Shanya, Maphis, Nicole M., Binder, Jessica, Chisholm, Devon, Weston, Lea, Duran, Walter, Peterson, Crina, Zimmerman, Amber, Mandell, Michael A., Jett, Stephen D., Bigio, Eileen, Geula, Changiz, Mellios, Nikolaos, Weick, Jason P., Rosenberg, Gary A., Latz, Eicke, Heneka, Michael T., Bhaskar, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491766/
https://www.ncbi.nlm.nih.gov/pubmed/34551296
http://dx.doi.org/10.1016/j.celrep.2021.109720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491766/
https://www.ncbi.nlm.nih.gov/pubmed/34551296
http://dx.doi.org/10.1016/j.celrep.2021.109720

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