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Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells

Mycotoxins are key risk factors in human food and animal feed. Most of food-origin mycotoxins could easily enter the organism and evoke systemic toxic effects, such as aflatoxin B1 (AFB1), ochratoxin A (OTA), T-2 toxin, deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), and 3-nitropropioni...

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Autores principales: Pei, Xingyao, Zhang, Wenjuan, Jiang, Haiyang, Liu, Dingkuo, Liu, Xinyu, Li, Liuan, Li, Cun, Xiao, Xilong, Tang, Shusheng, Li, Daowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492254/
https://www.ncbi.nlm.nih.gov/pubmed/34621467
http://dx.doi.org/10.1155/2021/9967334
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author Pei, Xingyao
Zhang, Wenjuan
Jiang, Haiyang
Liu, Dingkuo
Liu, Xinyu
Li, Liuan
Li, Cun
Xiao, Xilong
Tang, Shusheng
Li, Daowen
author_facet Pei, Xingyao
Zhang, Wenjuan
Jiang, Haiyang
Liu, Dingkuo
Liu, Xinyu
Li, Liuan
Li, Cun
Xiao, Xilong
Tang, Shusheng
Li, Daowen
author_sort Pei, Xingyao
collection PubMed
description Mycotoxins are key risk factors in human food and animal feed. Most of food-origin mycotoxins could easily enter the organism and evoke systemic toxic effects, such as aflatoxin B1 (AFB1), ochratoxin A (OTA), T-2 toxin, deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), and 3-nitropropionic acid (3-NPA). For the last decade, the researches have provided much evidences in vivo and in vitro that the brain is an important target organ on mycotoxin-mediated neurotoxic phenomenon and neurodegenerative diseases. As is known to all, glial cells are the best regulator and defender of neurons, and a few evaluations about the effects of mycotoxins on glial cells such as astrocytes or microglia have been conducted. The fact that mycotoxin contamination may be a key factor in neurotoxicity and glial dysfunction is exactly the reason why we reviewed the activation, oxidative stress, and mitochondrial function changes of glial cells under mycotoxin infection and summarized the mycotoxin-mediated glial cell proliferation disorders, death pathways, and inflammatory responses. The purpose of this paper is to analyze various pathways in which common food-derived mycotoxins can induce glial toxicity and provide a novel perspective for future research on the neurodegenerative diseases.
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spelling pubmed-84922542021-10-06 Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells Pei, Xingyao Zhang, Wenjuan Jiang, Haiyang Liu, Dingkuo Liu, Xinyu Li, Liuan Li, Cun Xiao, Xilong Tang, Shusheng Li, Daowen Oxid Med Cell Longev Review Article Mycotoxins are key risk factors in human food and animal feed. Most of food-origin mycotoxins could easily enter the organism and evoke systemic toxic effects, such as aflatoxin B1 (AFB1), ochratoxin A (OTA), T-2 toxin, deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), and 3-nitropropionic acid (3-NPA). For the last decade, the researches have provided much evidences in vivo and in vitro that the brain is an important target organ on mycotoxin-mediated neurotoxic phenomenon and neurodegenerative diseases. As is known to all, glial cells are the best regulator and defender of neurons, and a few evaluations about the effects of mycotoxins on glial cells such as astrocytes or microglia have been conducted. The fact that mycotoxin contamination may be a key factor in neurotoxicity and glial dysfunction is exactly the reason why we reviewed the activation, oxidative stress, and mitochondrial function changes of glial cells under mycotoxin infection and summarized the mycotoxin-mediated glial cell proliferation disorders, death pathways, and inflammatory responses. The purpose of this paper is to analyze various pathways in which common food-derived mycotoxins can induce glial toxicity and provide a novel perspective for future research on the neurodegenerative diseases. Hindawi 2021-09-28 /pmc/articles/PMC8492254/ /pubmed/34621467 http://dx.doi.org/10.1155/2021/9967334 Text en Copyright © 2021 Xingyao Pei et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pei, Xingyao
Zhang, Wenjuan
Jiang, Haiyang
Liu, Dingkuo
Liu, Xinyu
Li, Liuan
Li, Cun
Xiao, Xilong
Tang, Shusheng
Li, Daowen
Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title_full Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title_fullStr Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title_full_unstemmed Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title_short Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells
title_sort food-origin mycotoxin-induced neurotoxicity: intend to break the rules of neuroglia cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492254/
https://www.ncbi.nlm.nih.gov/pubmed/34621467
http://dx.doi.org/10.1155/2021/9967334
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