SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer

BACKGROUND: Immune checkpoint inhibitors (ICIs) fail to demonstrate efficacy in pancreatic cancer. Recently, genomic biomarkers have been associated with response to ICIs: microsatellite instability high (MSI-H) and tumor mutation burden (TMB) > 10 mutations/Mb. Alterations in Switch/Sucrose Nonf...

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Detalles Bibliográficos
Autores principales: Botta, Gregory P., Kato, Shumei, Patel, Hitendra, Fanta, Paul, Lee, Suzanna, Okamura, Ryosuke, Kurzrock, Razelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492298/
https://www.ncbi.nlm.nih.gov/pubmed/34375311
http://dx.doi.org/10.1172/jci.insight.150453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492298/
https://www.ncbi.nlm.nih.gov/pubmed/34375311
http://dx.doi.org/10.1172/jci.insight.150453

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