Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells

Immunotherapies are needed in the clinic that effectively suppress β cell autoimmunity and reestablish long-term self-tolerance in type 1 diabetes. We previously demonstrated that nondepleting anti-CD4 (αCD4) and αCD8α antibodies establish rapid and indefinite remission in recent-onset diabetic NOD...

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Detalles Bibliográficos
Autores principales: Clark, Matthew, Kroger, Charles J., Ke, Qi, Zhang, Rui, Statum, Karen, Milner, J. Justin, Martin, Aaron, Wang, Bo, Tisch, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492310/
https://www.ncbi.nlm.nih.gov/pubmed/34314385
http://dx.doi.org/10.1172/jci.insight.149130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492310/
https://www.ncbi.nlm.nih.gov/pubmed/34314385
http://dx.doi.org/10.1172/jci.insight.149130

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