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Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells
Immunotherapies are needed in the clinic that effectively suppress β cell autoimmunity and reestablish long-term self-tolerance in type 1 diabetes. We previously demonstrated that nondepleting anti-CD4 (αCD4) and αCD8α antibodies establish rapid and indefinite remission in recent-onset diabetic NOD...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492310/ https://www.ncbi.nlm.nih.gov/pubmed/34314385 http://dx.doi.org/10.1172/jci.insight.149130 |