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Lipin 1 modulates mRNA splicing during fasting adaptation in liver

Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activity) and transcriptional coactivation. Lipin 1–deficient individuals exhibit episodic disease symptoms that are triggered by metabolic stress, such as stress caused by pro...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Chan, Tracey W., Vashisht, Ajay A., Drew, Brian G., Calkin, Anna C., Harris, Thurl E., Wohlschlegel, James A., Xiao, Xinshu, Reue, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492312/
https://www.ncbi.nlm.nih.gov/pubmed/34494556
http://dx.doi.org/10.1172/jci.insight.150114