Mitochondrial dysfunction–induced H3K27 hyperacetylation perturbs enhancers in Parkinson’s disease

Mitochondrial dysfunction is a major pathophysiological contributor to the progression of Parkinson’s disease (PD); however, whether it contributes to epigenetic dysregulation remains unknown. Here, we show that both chemically and genetically driven mitochondrial dysfunctions share a common mechani...

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Detalles Bibliográficos
Autores principales: Huang, Minhong, Lou, Dan, Charli, Adhithiya, Kong, Dehui, Jin, Huajun, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Wang, Zhibin, Kanthasamy, Anumantha G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492320/
https://www.ncbi.nlm.nih.gov/pubmed/34494552
http://dx.doi.org/10.1172/jci.insight.138088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492320/
https://www.ncbi.nlm.nih.gov/pubmed/34494552
http://dx.doi.org/10.1172/jci.insight.138088

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