TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells

Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-mediated injury of transplants, by regulating innate B...

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Detalles Bibliográficos
Autores principales: de Mattos Barbosa, Mayara Garcia, Lefferts, Adam R., Huynh, Daniel, Liu, Hui, Zhang, Yu, Fu, Beverly, Barnes, Jenna, Samaniego, Milagros, Bram, Richard J., Geha, Raif S., Shikanov, Ariella, Prak, Eline T. Luning, Farkash, Evan A., Platt, Jeffrey L., Cascalho, Marilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492324/
https://www.ncbi.nlm.nih.gov/pubmed/34283811
http://dx.doi.org/10.1172/jci.insight.150483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492324/
https://www.ncbi.nlm.nih.gov/pubmed/34283811
http://dx.doi.org/10.1172/jci.insight.150483

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