Pancreas-specific CHRM3 activation causes pancreatitis in mice

Hyperstimulation of the cholecystokinin 1 receptor (CCK1R), a G protein–coupled receptor (GPCR), in pancreatic acinar cells is commonly used to induce pancreatitis in rodents. Human pancreatic acinar cells lack CCK1R but express cholinergic receptor muscarinic 3 (M3R), another GPCR. To test whether...

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Detalles Bibliográficos
Autores principales: Wan, Jianhua, Wang, Jiale, Wagner, Larry E., Wang, Oliver H., Gui, Fu, Chen, Jiaxiang, Zhu, Xiaohui, Haddock, Ashley N., Edenfield, Brandy H., Haight, Brian, Mukhopadhyay, Debabrata, Wang, Ying, Yule, David I., Bi, Yan, Ji, Baoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492327/
https://www.ncbi.nlm.nih.gov/pubmed/34314386
http://dx.doi.org/10.1172/jci.insight.132585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492327/
https://www.ncbi.nlm.nih.gov/pubmed/34314386
http://dx.doi.org/10.1172/jci.insight.132585

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